Skip to content

GI Update

Per-oral Endoscopic Myotomy (POEM) for Treatment of Achalasia

New approaches to treating achalasia, a neuromuscular condition marked by difficulty swallowing, successfully reduce esophageal sphincter pressure, while avoiding the need for laparoscopic surgery. The standard surgical option for achalasia is Heller myotomy, a laparoscopic procedure in which the muscles of the lower esophageal sphincter are divided to provide durable reduction in esophageal sphincter pressure. Other effective treatments include esophageal dilation with large balloons, which has high recurrence, and Botox injection, which is much less durable.

According to Eric M. Pauli, MD, a general surgeon at Penn State Health Milton S. Hershey Medical Center, “A newer, incision-free, per-oral endoscopic myotomy (POEM) technique shows promise as a safe, effective alternative.” In his animal lab, Abraham Mathew, MD, gastroenterologist from Penn State Hershey Gastroenterology and Hepatology, initially developed transesophageal endoscopic dissection techniques in a porcine model specifically aimed at reaching the esophageal muscle.1 Physicians in Japan were the first to perform the technique in humans.2 POEM is now performed in a small number of centers in the United States and around the world,3 and the Medical Center was the first to use this technique in Pennsylvania. Dr. Pauli notes, “This is an exciting opportunity to treat achalasia patients using no incision; the procedure is completely endoscopic and yields intermediate-term results equal to those of a Heller myotomy.”

Per-oral Endoscopic Myotomy (POEM): Figure 1: Sub-mucosal tunnel creation extending towards the GE junction. Figure 2: Circular muscle fibers division maintaining intact longitudinal fibers beneath.

Per-oral Endoscopic Myotomy (POEM): Figure 1: Sub-mucosal tunnel creation extending towards the GE junction. Figure 2: Circular muscle fibers division maintaining intact longitudinal fibers beneath.

Drs. Pauli and Mathew are now working together to establish POEM as the new standard of care for treating achalasia in properly selected patients. All patients with achalasia are evaluated for their candidacy for POEM regardless of their age and prior achalasia therapy (including prior Botox injections, dilation, or surgical myotomy). Dr. Pauli, who completed a fellowship at Case Western University in Cleveland, Ohio, where he learned the POEM technique,4 believes that working with a gastroenterologist is key to successfully treating patients with achalasia. Dr. Mathew agrees, noting, “We perform each POEM procedure as a team, with overlapping skills. I have expertise with interventional endoscopy and submucosal dissection; Eric [Pauli] applies his skills with surgical dissection and myotomy. If complications arise, we have backup for laparoscopic or open surgery.”

Gastric reflux commonly occurs after the procedure, affecting about 20 percent of patients, but is treatable with standard therapy. Rarely, patients who undergo either type of myotomy experience esophageal leaks, which may require intervention. Drs. Pauli and Mathew have found their POEM patients to experience less pain and return to daily activities within a day or two, compared to patients who have undergone Heller myotomy, where recovery may take several days. “With far less dissection, no dermal incisions, and no need for fundoplication to prevent reflux, there is little post-operative pain, no risk of hernia, and limited risk of infection,” notes Dr. Mathew.

A complication uniquely associated with POEM is mediastinal accumulation of CO2 in the chest wall, which can lead to partial lung collapse; however, this is usually self-limited and requires no therapy. Moving forward, Drs. Pauli and Mathew intend to closely follow outcomes in all patients for whom they perform POEM, to better understand the risks and benefits with the new procedure. Dr. Pauli says, “POEM appears to be a safe and preferred alternative to Heller myotomy and is rapidly becoming the new standard of care.”

A head-and-shoulders photo of Eric M. Pauli, MD

Eric M. Pauli, MD

Assistant Professor of Surgery
Director of Endoscopic Surgery
Phone: 717-531-8887
Fellowship: Laparoendoscopic Surgery, University Hospitals Case Medical Center
Residency: General Surgery, Penn State Health Milton S. Hershey Medical Center; Internship: General Surgery, Penn State Health Milton S. Hershey Medical Center
Medical School: Penn State College of Medicine
Connect with Eric M. Pauli, MD, on Doximity

A head-and-shoulders photo of Abraham Mathew, MD

Abraham Mathew, MD

Professor of Medicine
Phone: 717-531-1441
Fellowship: Gastroenterology, Penn State Health Milton S. Hershey Medical Center
Residency: Internal Medicine, Abington Memorial Hospital
Medical School: Mahatma Gandhi University
Connect with Penn State Health Gastroenterology and Hepatology on Doximity


  1. Pauli EM, Mathew, et al. Technique for transesophageal endoscopic cardiomyotomy (Heller myotomy). Surg Endosc. 2008 Oct; 22(10):2279-80
  2. Inoue H, Minami H, Kobayashi Y, et al. Per oral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy. 2010; 42 (4):265–271.
  3. Meireles OR, Horgan S, Jacobsen GR, Katagiri T, Mathew A, Sedrak M, Sandler BJ, Dotai T, Savides TJ, Majid SF, Nijhawan S, Talamini MA. Transesophageal endoscopic myotomy (TEEM) for the treatment of achalasia: the United States human experience. Surg Endosc. 2013 May; 27(5):1803-9.
  4. Ponsky, JL, Marks, JM, Pauli EM. How I do it: Per-oral endoscopic myotomy (POEM). J Gastrointest Surg. 2012; 16(6):1251-55.

Penn State Health Gastroenterology and Hepatology provides comprehensive services in the diagnosis, medical management and endoscopic treatment of diseases affecting the digestive system and liver.

Penn State Health Colon and Rectal Surgery consists of highly skilled, board-certified surgeons specializing in the treatment of patients with complicated colorectal disease. Each surgeon uses advanced diagnostic capabilities, the latest drug therapies, and leading-edge surgical techniques to provide the most effective medical care possible.

The mission of Penn State Health Gastroenterology and Hepatology and Penn State Health Colorectal Surgery is to provide world-class care and to advance the knowledge of disorders of the digestive system and liver through research, as well as to train the physicians of the future. The physicians participate in studies to determine the usefulness of novel treatments through clinical research studies and also in research which advances the basic knowledge of the disorders in this field.

Refer a patient

Continuing Education activities

View Programs

Stay informed of all Continuing Education activities that interest you.

Subscribe Today